Razvan L. Cornea
University of Minnesota – Department of Biochemistry, Molecular Biology and Biophysics (BMBB)
Mailing address: 6-155 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455
E-mail address: corne002@umn.edu
Phone: (612) 626-2660
Mailing address: 6-155 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455
E-mail address: corne002@umn.edu
Phone: (612) 626-2660
Education
- 1988 B.S. – University of Bucharest, Romania – Biochemistry
- 1994 M.S. – University of Minnesota (D.D. Thomas) – Biophysics/Biochemistry
- 1996 Ph.D. – University of Minnesota (D.D. Thomas) – Biophysics/Biochemistry
Postdoctoral Training
- 1997-2001 Postdoctoral Associate – University of Minnesota (D.D. Thomas)
- 1997 - 2001 Postdoctoral Fellow – Indiana University (L.R. Jones)
- 2000 - 2001 Postdoctoral Fellow – University of Minnesota (C.F. Louis)
Positions & Employment
- 07/2001 - 01/2004 Research Associate – University of Minnesota School of Medicine – BMBB
- 01/2004 - 05/2013 Assistant Professor – University of Minnesota School of Medicine – BMBB
- 05/2013 - present Associate Professor – University of Minnesota School of Medicine – BMBB
- 10/2014 - present Co-founder and VP of Research – Photonic Pharma LLC
Other Experience and Professional Affiliations
- 1992 - present Biophysical Society Member
- 2007 - present Consultant for Celladon, Inc.
- 2012 - present Paul and Sheila Wellstone Muscular Dystrophy Center Member
- 2013 - present American Heart Association Member
- 2014 - present International Society for Heart Research Member
- 2015 - present NIH BST-55 High-Throughput Screening Review Panel
- Reviewer for Biophysical Journal, Biochemistry, Circulation Research, Journal of Bimolecular Screening, Proceedings of the National Academy of Science (PNAS)
Awards
- 07/1998 - 06/2001 American Heart Association – Postdoctoral Fellowship (PI).
- 07/2002 - 06/2004 American Heart Association – Northland Affiliate Beginning Grant-in-Aid (PI).
- 07/2005 - 06/2010 NIH R01HL076433 – Molecular interactions regulating RyR calcium channels (PI: Brad Fruen; Co-I: Razvan Cornea).
- 11/2006 - 10/2007 Minnesota Medical Foundation – Faculty Research Grant, Fluorescent FKBP12 Probes for Ryanodine Receptor Calcium Channels (PI).
- 01/2008 - 02/2009 Celladon Corporation – Research Grant, A Fluorescence-Based Assay for the Phospholamban-SERCA Interaction (PI).
- 01/2010 - 12/2013 NIH R01HL092097 – FKBP Interaction with RyR Calcium Channels in Heart (PI: Donald Bers; PI of U of MN subcontract: Razvan Cornea).
- 05/2014 - 04/2018 NIH R01HL092097 – Pathophysiological Regulation of Cardiac Myocyte RyR Channel (MPI: Donald Bers and Razvan Cornea)
- 07/2015 - 06/2017 AHA 15GRNT25610022 – High-Throughput Screens to Discover Small-Molecule RyR2 Modulators for Heart Failure Therapy (PI: Razvan Cornea).
- 01/2018 - 11/2021 NIH R01HL138539 – High-Throughput Screens to Discover Novel Inhibitors of Leaky RyR2 for Heart Failure Therapy (MPI: Bers, Cornea-contact, Mercola).
- 01/2019 - 12/2022 NIH R01HL092097 – Calmodulin-Dependent Regulation of Cardiac Ryanodine Receptor (MPI: Bers-contact and Cornea).
- 11/2019 - 10/2020 Medical School/UMF Equipment Award E-0919-01 IonOptix Imaging System for simultaneous Detection of Myocyte Calcium and Contractility. (PI: Razvan Cornea)
- 11/2020 - 12/2021 RYR-1 Foundation Individual Research Grant – High-Throughput Screens to Discover Novel Modulators of Dysfunctional RyR1 Channels for Therapeutic Development. (PI: Razvan Cornea)
- 03/2020 - 02/2024 NIH R01HL151223 – Development of a Mirror-Image Natural Product as an Antiarrhythmic Therapeutic (PI: Johnston and Cornea-subcontract PI)
- 05/2020 - 04/2024 9R01HL139065-36 – Structural Dynamics of Cardiac Muscle Calcium ATPase Regulation (MPI: Cornea, Thomas)
Patents
- U.S. patent 8,431,356: Fluorescence resonance energy transfer assays for sarco/endoplasmic reticulum calcium ATPase and phospholamban (inventors: David D. Thomas, Razvan L. Cornea, Krisztina M. Zsebo). Issued April 30, 2013.
- U.S. patent 10,794,898: High-throughput, high-precision methods for detecting protein structural changes in living cells (inventors, David D. Thomas, Simon J. Gruber, Razvan L. Cornea, Gregory D. Gillispie, Seth L. Robia). Issued October 6, 2020.
- U.S. patent 10,794,898: High-throughput, high-precision methods for detecting protein structural changes in living cells (inventors, David D. Thomas, Simon J. Gruber, Razvan L. Cornea, Gregory D. Gillispie, Seth L. Robia). Issued October 6, 2020.