Razvan L. Cornea

University of Minnesota – Department of Biochemistry, Molecular Biology and Biophysics (BMBB)
​Mailing address: 6-155 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455
E-mail address: corne002@umn.edu
Phone: (612) 626-2660
Education
  • 1988     B.S. – University of Bucharest, Romania – Biochemistry
  • 1994     M.S. – University of Minnesota (D.D. Thomas) – Biophysics/Biochemistry
  • ​1996     Ph.D. – University of Minnesota (D.D. Thomas) – Biophysics/Biochemistry
Postdoctoral Training
  • 1997-2001       Postdoctoral Associate – University of Minnesota (D.D. Thomas)
  • 1997 - 2001     Postdoctoral Fellow – Indiana University (L.R. Jones)
  • 2000 - 2001     Postdoctoral Fellow – University of Minnesota (C.F. Louis)
Positions & Employment​​
  • 07/2001 - 01/2004    Research Associate – University of Minnesota School of Medicine – BMBB
  • 01/2004 - 05/2013    Assistant Professor – University of Minnesota School of Medicine – BMBB
  • 05/2013 - present      Associate Professor – University of Minnesota School of Medicine – BMBB
  • 10/2014 - present      Co-founder and VP of Research – Photonic Pharma LLC
Other Experience and Professional Affiliations
  • 1992 - present      Biophysical Society Member
  • 2007 - present      Consultant for Celladon, Inc.
  • 2012 - present      Paul and Sheila Wellstone Muscular Dystrophy Center Member
  • 2013 - present      American Heart Association Member
  • 2014 - present      International Society for Heart Research Member
  • 2015 - present      NIH BST-55 High-Throughput Screening Review Panel
  • Reviewer for Biophysical Journal, Biochemistry, Circulation Research, Journal of Bimolecular Screening, Proceedings of the National Academy of Science (PNAS)
Awards
  • 07/1998 - 06/2001     American Heart Association – Postdoctoral Fellowship (PI).
  • 07/2002 - 06/2004     American Heart Association – Northland Affiliate Beginning Grant-in-Aid (PI).
  • 07/2005 - 06/2010     NIH R01HL076433 – Molecular interactions regulating RyR calcium channels (PI: Brad Fruen; Co-I: Razvan Cornea). 
  • 11/2006 - 10/2007     Minnesota Medical Foundation – Faculty Research Grant, Fluorescent FKBP12 Probes for Ryanodine Receptor Calcium Channels (PI).
  • 01/2008 - 02/2009     Celladon Corporation – Research Grant, A Fluorescence-Based Assay for the Phospholamban-SERCA Interaction (PI).
  • 01/2010 - 12/2013     NIH R01HL092097 – FKBP Interaction with RyR Calcium Channels in Heart (PI: Donald Bers; PI of U of MN subcontract: Razvan Cornea).
  • 05/2014 - 04/2018     NIH R01HL092097 – Pathophysiological Regulation of Cardiac Myocyte RyR Channel (MPI: Donald Bers and Razvan Cornea)
  • 07/2015 - 06/2017     AHA 15GRNT25610022 – High-Throughput Screens to Discover Small-Molecule RyR2 Modulators for Heart Failure Therapy (PI: Razvan Cornea).
  • 01/2018 - 11/2021     NIH R01HL138539 – High-Throughput Screens to Discover Novel Inhibitors of Leaky RyR2 for Heart Failure Therapy (MPI: Bers, Cornea-contact, Mercola).
  • 01/2019 - 12/2022     NIH R01HL092097 – Calmodulin-Dependent Regulation of Cardiac Ryanodine Receptor (MPI: Bers-contact and Cornea).
  • 11/2019 - 10/2020     Medical School/UMF Equipment Award E-0919-01 IonOptix Imaging System for simultaneous Detection of Myocyte Calcium and Contractility. (PI: Razvan Cornea)
  • 11/2020 - 12/2021     RYR-1 Foundation Individual Research Grant – High-Throughput Screens to Discover Novel Modulators of Dysfunctional RyR1 Channels for Therapeutic Development. (PI: Razvan Cornea)
  • 03/2020 - 02/2024     NIH R01HL151223 – Development of a Mirror-Image Natural Product as an Antiarrhythmic Therapeutic (PI: Johnston and Cornea-subcontract PI)
  • 05/2020 - 04/2024     9R01HL139065-36 – Structural Dynamics of Cardiac Muscle Calcium ATPase Regulation (MPI: Cornea, Thomas)
Patents
  • U.S. patent 8,431,356:  Fluorescence resonance energy transfer assays for sarco/endoplasmic reticulum calcium ATPase and phospholamban (inventors: David D. Thomas, Razvan L. Cornea, Krisztina M. Zsebo). Issued April 30, 2013.
  • U.S. patent 10,794,898: High-throughput, high-precision methods for detecting protein structural changes in living cells (inventors, David D. Thomas, Simon J. Gruber, Razvan L. Cornea, Gregory D. Gillispie, Seth L. Robia). Issued October 6, 2020.
  • U.S. patent 10,794,898: High-throughput, high-precision methods for detecting protein structural changes in living cells (inventors, David D. Thomas, Simon J. Gruber, Razvan L. Cornea, Gregory D. Gillispie, Seth L. Robia). Issued October 6, 2020.​