Publications
1. High-throughput screens to discover small-molecule modulators of ryanodine receptor calcium release channels.
Rebbeck RT, Essawy MM, Nitu FR, Grant BD, Gillispie GD, Thomas DD, Bers DM, Cornea RL.
Journal of Bimolecular Screening. 2016.
ABSTRACT
2. CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift.
Uchinoumi H, Yang Y, Oda T, Li N, Alsina KM, Puglisi JL, Chen-Izu Y, Cornea RL, Wehrens XHT, Bers DM.
Journal of Molecular and Cellular Cardiology. 2016.
ABSTRACT
3. S100A1 protein does not compete with calmodulin for ryanodine receptor binding but structurally alters the ryanodine receptor/calmodulin complex.
Rebbeck RT, Nitu FR, Rohde D, Most P, Bers DM, Thomas DD, Cornea RL.
The Journal of Biological Chemistry. 2016.
ABSTRACT
4. Crystal structures of ryanodine receptor SPRY1 and tandem-repeat domains reveal a critical FKBP12 binding determinant.
Yuchi Z, Yuen SM, Lau K, Underhill AQ, Cornea RL, Fessenden JD, Van Petegem F.
Nature Communications. 2015.
ABSTRACT
5. Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity.
Oda T, Yang Y, Uchinoumi H, Thomas DD, Chen-Izu Y, Kato T, Yamamoto T, Yano M, Cornea RL, Bers DM.
Journal of Molecular and Cellular Cardiology. 2015.
ABSTRACT
6. FRET-based trilateration of probes bound within functional ryanodine receptors.
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7. Structural mapping of divergent regions in the type 1 ryanodine receptor using fluorescence resonance energy transfer.
Mahalingam M, Girgenrath T, Svensson B, Thomas DD, Cornea RL, Fessenden JD.
Structure (London, England : 1993). 2014.
ABSTRACT
8. Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants.
Hwang HS, Nitu FR, Yang Y, Walweel K, Pereira L, Johnson CN, Faggioni M, Chazin WJ, Laver D, George AL Jr, Cornea RL, Bers DM, Knollmann BC.
Circulation Research. 2014.
ABSTRACT
9. Discovery of enzyme modulators via high-throughput time-resolved FRET in living cells.
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10. Cardiac myocyte Z-line calmodulin is mainly RyR2-bound, and reduction is arrhythmogenic and occurs in heart failure.
Yang Y, Guo T, Oda T, Chakraborty A, Chen L, Uchinoumi H, Knowlton AA, Fruen BR, Cornea RL, Meissner G, Bers DM.
Circulation Research. 2014.
ABSTRACT
Patents
U.S. patent 8,431,356: Fluorescence resonance energy transfer assays for sarco/endoplasmic reticulum calcium ATPase and phospholamban. Inventors: David D. Thomas, Razvan L. Cornea, and Krisztina M. Zsebo.
U.S. patent application no. 14/565,811: FRET-based high-throughput screening methods to discover modulators of RyR calcium channels Inventors: Razvan L. Cornea, Donald M. Bers, David D. Thomas, Gregory D. Gillispie. Filed Dec.10, 2014.
U.S. patent application no. 14/598,707: High-throughput, high-precision methods for detecting protein structural changes in living cells Inventors: David D. Thomas, Simon J. Gruber, Razvan L. Cornea, Gregory D. Gillispie, Seth L. Robia. Filed Jan. 16, 2015.
U.S. patent application no. 14/565,811: FRET-based high-throughput screening methods to discover modulators of RyR calcium channels Inventors: Razvan L. Cornea, Donald M. Bers, David D. Thomas, Gregory D. Gillispie. Filed Dec.10, 2014.
U.S. patent application no. 14/598,707: High-throughput, high-precision methods for detecting protein structural changes in living cells Inventors: David D. Thomas, Simon J. Gruber, Razvan L. Cornea, Gregory D. Gillispie, Seth L. Robia. Filed Jan. 16, 2015.