Publications |
• The functional significance of redox-mediated inter subunit cross-linking in regulation of human type 2 ryanodine receptor.
Nikolaienko R, Bovo E, Rebbeck RT, Kahn D, Thomas DD, Cornea RL, Zima AV.
Redox Biology. 2020.
ABSTRACT
• Live-cell cardiac-specific high-throughput screening platform for drug-like molecules that enhance Ca2+ transport.
Schaaf TM, Kleinboehl E, Yuen SL, Roelike LN, Svensson B, Thompson AR, Cornea RL, Thomas DD.
Cells. 2020.
ABSTRACT
• Resolved structural states of calmodulin in regulation of skeletal muscle calcium release.
McCarthy MR, Savich Y, Cornea RL, Thomas DD.
Biophysical Journal. 2020.
ABSTRACT
• RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays.
Rebbeck RT, Singh DP, Janicek KA, Bers DM, Thomas DD, Launikonis BS, Cornea RL.
Nature Scientific Reports. 2020.
ABSTRACT
•Mechanical factors tune the sensitivity of mdx muscle to eccentric strength loss and its protection by antioxidant and calcium modulators.
Lindsay A, Baumann CW, Rebbeck RT, Yuen SL, Southern WM, Hodges JS, Cornea RL, Thomas DD, Ervasti JM, Lowe DA.
Skeletal Muscle. 2020.
ABSTRACT
• Viral expression of a SERCA2a-activating PLB mutant improves calcium cycling and synchronicity in dilated cardiomyopathy hiPSC-CMs.
Stroik D, Ceholski DK, Bidwell PA, Mleczko J, Thanel PF, Kamdar F, Autry JM, Cornea RL, Thomas DD.
Journal of Molecular and Cellular Cardiology. 2019.
ABSTRACT
• The CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of Nav1.5 and RyR2 function.
Johnson CN, Pattanayek R, Potet F, Rebbeck RT, Blackwell DJ, Nikolaienko R, Sequeira V, Le Muer R, Radwański PB, Davis JP, Zima AV, Cornea RL, Damo SM, Györke S, George AL Jr, Knollman BC.
Cell Calcium. 2019.
ABSTRACT
• Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814.
Walweel K, Gomez-Hurtado N, Rebbeck RT, Oo YW, Beard NA, Molenaar P, Dos Remedios C, van Helden DF, Cornea RL, Knollmann BC, Laver DR.
Journal of Molecular and Cellular Cardiology. 2019.
ABSTRACT
• Unnatural verticilide enantiomer inhibits type 2 ryandodine receptor-mediated calcium leak and is antiarrhythmic.
Batiste SM, Blackwell DJ, Kim K, Kryshtal DO, Gomez-Hurtado N, Rebbeck RT, Cornea RL, Johnston JN, Knollman BC.
Proceedings of the National Academy of Sciences of the United States of America. 2019
ABSTRACT
• Targeting protein-protein interactions for therapeutic discovery via FRET-based high-throughput screening in living cells.
Rebbeck RT, Essawy MM, Nitu FR, Grant BD, Gillispie GD, Thomas DD, Bers DM, Cornea RL.
Scientific Reports. 2018.
ABSTRACT
• High-throughput screens to discover small-molecule modulators of ryanodine receptor calcium release channels.
Rebbeck RT, Essawy MM, Nitu FR, Grant BD, Gillispie GD, Thomas DD, Bers DM, Cornea RL.
SLAS Discovery: Advancing Life Sciences R & D. 2017.
ABSTRACT
• CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift.
Uchinoumi H, Yang Y, Oda T, Li N, Alsina KM, Puglisi JL, Chen-Izu Y, Cornea RL, Wehrens XHT, Bers DM.
Journal of Molecular and Cellular Cardiology. 2016.
ABSTRACT
• S100A1 protein does not compete with calmodulin for ryanodine receptor binding but structurally alters the ryanodine receptor/calmodulin complex.
Rebbeck RT, Nitu FR, Rohde D, Most P, Bers DM, Thomas DD, Cornea RL.
The Journal of Biological Chemistry. 2016.
ABSTRACT
Patents
U.S. patent 8,431,356: Fluorescence resonance energy transfer assays for sarco/endoplasmic reticulum calcium ATPase and phospholamban (inventors: David D. Thomas, Razvan L. Cornea, Krisztina M. Zsebo). Issued April 30, 2013.
U.S. patent 10,281,476: FRET-based high-throughput screening methods to discover modulators of RyR calcium channels (inventors: Razvan L. Cornea, Donald M. Bers, David D. Thomas, Gregory D. Gillispie). Issued May 7, 2019.
U.S. patent 10794898: High-throughput, high-precision methods for detecting protein structural changes in living cells (inventors, David D. Thomas, Simon J. Gruber, Razvan L. Cornea, Gregory D. Gillispie, Seth L. Robia). Issued October 6, 2020.
U.S. patent 10,281,476: FRET-based high-throughput screening methods to discover modulators of RyR calcium channels (inventors: Razvan L. Cornea, Donald M. Bers, David D. Thomas, Gregory D. Gillispie). Issued May 7, 2019.
U.S. patent 10794898: High-throughput, high-precision methods for detecting protein structural changes in living cells (inventors, David D. Thomas, Simon J. Gruber, Razvan L. Cornea, Gregory D. Gillispie, Seth L. Robia). Issued October 6, 2020.